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Adjuvant oils induce arthritis in the DA rat. I. Characterization of the disease and evidence for an immunological involvement

Identifieur interne : 001426 ( Main/Exploration ); précédent : 001425; suivant : 001427

Adjuvant oils induce arthritis in the DA rat. I. Characterization of the disease and evidence for an immunological involvement

Auteurs : Sandra Kleinau [Suède] ; Helena Erlandsson [Suède] ; Rikard Holmdahl [Suède] ; Lars Klareskog [Suède]

Source :

Journal of Autoimmunity [ 0896-8411 ] ; 1991.

RBID : ISTEX:EE39C5EB8E340FC061D60617F9068EEA5F72961A

English descriptors

Teeft :
- Adjuvant, Ankle joints, Apparent arthritis, Arthritis, Arthritis rheum, Arthritogenicity, Blood samples, Blood smears, Clinical signs, Collagen, Dark agouti, Different times, Heat shock protein, Histological examination, Histopathological examinations, Human proteoglycan, Incomplete adjuvant, Injection, Intradermal injection, Joint space, Kleinau, Lewis rats, Lymph node cells, Marginal erosion, Microtiter plates, Mononuclear cells, Multinucleated giant cells, Mycobacteria, Mycobacteria tuberculosis, Original magnification, Other types, Polymorphonuclear cells, Pristane, Rat, Sandra, Sandra kleinau, Single injection, Specific immunity, Subchondral bone, Synovial subintimal tissue, Vegetable oils.

Abstract

Abstract: An intradermal injection of Freund's incomplete adjuvant oil (FIA) without further additives was shown to induce erosive polyarthritis in dark Agouti (DA) rats, but not in Lewis rats. Histological examination revealed joint inflammation, first with polymorphonuclear cells and synovial hyperplasia, and subsequently, with multinucleated giant cells. Both constituents of FIA, mineral oil and Arlacel® A, as well as Pristane oil were arthritogenic, whereas vegetable oils were not. Re-administration of adjuvant oil after recovery failed to induce arthritis, thus making possible a role of specific immunity in this new form of arthritis in rats.

Url:

https://api.istex.fr/ark:/67375/6H6-31J1D94N-L/fulltext.pdf

DOI: 10.1016/0896-8411(91)90050-M

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: An intradermal injection of Freund's incomplete adjuvant oil (FIA) without further additives was shown to induce erosive polyarthritis in dark Agouti (DA) rats, but not in Lewis rats. Histological examination revealed joint inflammation, first with polymorphonuclear cells and synovial hyperplasia, and subsequently, with multinucleated giant cells. Both constituents of FIA, mineral oil and Arlacel® A, as well as Pristane oil were arthritogenic, whereas vegetable oils were not. Re-administration of adjuvant oil after recovery failed to induce arthritis, thus making possible a role of specific immunity in this new form of arthritis in rats.</div>
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Adjuvant oils induce arthritis in the DA rat. I. Characterization of the disease and evidence for an immunological involvement

Adjuvant oils induce arthritis in the DA rat. I. Characterization of the disease and evidence for an immunological involvement

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri